Metabolomics Testimonials
Prof. Doug Kell & Dr. Rick Dunn of Manchester University - Pegasus GCxGC-TOF/MS & GC-TOF/MS
"At the University of Manchester's Bioanalytical Sciences Group we purchased a LECO Pegasus III GC-TOF-MS system in Autumn 2003 to be used for metabolomics studies (specifically metabolic profiling) of microbial and mammalian systems. The deconvolution software and high acquisition rates achievable allow the analysis of complex samples containing many 100s -1000s of peaks.
The system has proved to be both robust and reliable and is used in high-throughput studies, which are assisted by no requirement to clean the ion source due to its large and innovative design.
In Spring 2005 we purchased a LECO Pegasus 4D GCxGC-TOF-MS instrument. This comprehensive system enhances chromatographic resolution of complex mammalian metabolomic samples and provides higher sensitivity compared to GC-TOF-MS systems. Additionally, GCxGC-TOF-MS provides improved identification capabilities by the temporal separation of background chemical noise from metabolite peaks, assisting a known & important difficulty of metabolomics work."
Dr Warwick Dunn
Experimental Officer (Metabolomics/Mass Spectrometry)
Manchester Centre for Integrative Systems Biology
University of Manchester
Prof. Mike Beale & Dr. Jane Ward of the The National Centre for Plant and Microbial Metabolomics at Rothamsted Research Institute - Pegasus III GC-TOF/MS
"This instrument was recently acquired and is used exclusively for metabolomics projects. The GC is fitted with a Gerstal MPS2 autosampler, providing a platform for automated sample preparation and advanced automated sampling techniques. The Pegasus is extremely sensitive, robust and reliable. It has high mass spectral acquisition rates, spectral deconvolution algorithms, fully automated data analysis and innovative maintenance-free source design."
